The WWARN Informatics Team manage data by transforming data sets into a common format which allows WWARN Study Group participants to pose important research questions and undertake large-scale pooled analyses to identify important trends or gaps in information. The Informatics team develops and maintains software that:
- Accepts data in any file format and transforms the data into a standard format and stores this in a relational database
- Provides a secure, data repository containing standardised patient level and study level data (WWARN is a recognised re3data repository.)
- Performs data analysis, on the standardised data, producing outcomes in a consistent way across all studies
- Maintains an audit trail of all data management, transformation and analysis processes
- Creates a set of automated study reports for each study
Filling the research gaps
- Parasite Clearance Estimator: an accurate, consistent method of clearance rate estimation, the rate at which parasitaemia declines and an important measure of drug efficacy
- In Vitro Analysis and Reporting Tool (IVART): automated web-based system for transforming and analysing (using an algorithm based on the INSERM-developed ICEstimator), and producing comprehensive reports on datasets large and small. IVART generates standardised reproducible IC50 estimates and can quickly process large batches of in vitro data.
Data Visualisation Tools
- WWARN Explorer: online, interactive visualisation tool allows users to customise and filter study summary data by drug, geographic region, parasite species, time and data type
- WWARN Molecular Surveyor: an interactive map summarising the location and incidence of molecular markers of chloroquine, amodiaquine and lumefantrine resistance in Plasmodium falciparum pfcrt and pfmdr1 genes compiled from published and unpublished data
- Antimalarial Quality Surveyor: will tabulate and map reports of antimalarial quality with summary data for individual surveys
To find out more about our Informatics activities, email: info [at] wwarn [dot] org
