Clinical Trials Publication Library Methodology

A quarterly literature search in PubMed, Embase and Web of Science is conducted with the following search terms:

Search terms are as follows;

((malaria OR plasmodium) AND (artefenomel OR arterolane OR amodiaquine OR atovaquone OR artemisinin OR arteether OR artesunate OR artemether OR artemether OR artemotil OR azithromycin OR artekin OR chloroquine OR chlorproguanil OR cycloguanil OR clindamycin OR coartem OR dapsone OR dihydroartemisinin OR duo-cotecxin OR doxycycline OR halofantrine OR lumefantrine OR lariam OR malarone OR mefloquine OR naphthoquine OR naphthoquinone OR piperaquine OR primaquine OR proguanil OR pyrimethamine OR pyronaridine OR proguanil OR quinidine OR quinine OR riamet OR sulphadoxine OR tetracycline OR tafenoquine))

OR (((((malaria OR plasmodium)) AND (resistance OR susceptibility OR sensitivity)) AND (in vitro OR ex vivo)) AND (artefenomel OR arterolane OR amodiaquine OR atovaquone OR artemisinin OR arteether OR artesunate OR artemether OR artemether OR artemotil OR azithromycin OR artekin OR benflumetol OR chloroquine OR chlorproguanil OR cycloguanil OR clindamycin OR coartem OR dapsone OR desethylamodiaquine OR dihydroartemisinin OR duo-cotecxin OR doxycycline OR halofantrine OR lumefantrine OR lariam OR malarone OR mefloquine OR monodesethylamodiaquine OR naphthoquine OR naphthoquinone OR piperaquine OR proguanil OR pyrimethamine OR pyronaridine OR proguanil OR quinine OR riamet OR sulphadoxine OR tetracycline OR tafenoquine))

After de-duplication, filtering for relevant studies is completed using the following criteria;

Inclusion criteria:

(a) prospective clinical studies assessing the efficacy of an antimalarial with at least 28 days follow-up

Exclusion criteria include:

(a) Animal models

(b) Publications only including severe malaria

(c) Studies with follow up <28 days

(d) Data previously included in another published study

(e) Prophylaxis studies

(f) IPT/IST studies

(g) MDA (mass drug administration)

(h) Healthy volunteer/Challenge studies

(i) Asymptomatic patient studies

In addition the Cochrane Database of Systematic Reviews is searched annually, and any other studies not previously identified are added. Study meta data on treatments, patient recruitment criteria, and site locations are extracted and entered into a standardised database. For location information if the site is not identified the capital city of the country is recorded, latitude and longitude are recorded according to Google maps.