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Kelch markers toolkit

WWARN has developed a guide for reporting minimal essential information for tracking Plasmodium falciparum kelch 13 molecular markers of drug resistance.

 

Parasite resistance to drugs for treating malaria threatens global malaria elimination goals. For example, mutations in the Plasmodium falciparum Kelch 13 protein are associated with artemisinin resistance which first emerged in Southeast Asia and is now likely to spread within Africa. Read more about WWARN’s work to track resistance using the kelch 13 gene.

It is essential to have tools that can help track this phenomenon's evolution geographically and overtime to inform local, regional, and global policymakers.

The kelch markers toolkit can be used to assess minimal essential information from studies evaluating malaria kelch 13 markers that make them suitable for pooling with other such data.

The tool consists of four excel sheets: information about the tool (P1-About), the tool itself - fields to complete about the study data (P2-Tool), the variables’ meta-data (P3-Variables) and further instructions (P4-Instructions). Download the tool.

For further information about the toolkit or contributing molecular markers of resistance data to WWARN, please contact info [at] wwarn [dot] org.

 Spatial distribution of K13 markers in Asia by 2018. This map was produced from the pooling of published data between 2010 – 2020

Figure: Spatial distribution of K13 markers in Asia by 2018. This map was produced from the pooling of published data between 2010 – 2020.