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On-site monitoring
Procedure
For when an investigator/institution takes responsibility for on-site monitoring of a clinical trial
Version: 2.0
Author: WWARN
Safety assessment and reporting
Procedure
A process for the identification, management, assessment, and reporting of adverse events/adverse drug reactions
Version: v1.0
Author: WWARN
Methods and techniques for assessing exposure to antimalarial drugs in clinical field studies
Publications
Estimation of Plasmodium falciparum drug susceptibility ex vivo by HRP2 ELISA
Procedure
Drug susceptibility assay measuring histidine-rich protein production by ELISA in fresh isolates
Version: v1.0
Author: WWARN
Agarose Gel Electrophoresis of msp1, msp2 and glurp
Procedure
Separating and visualising amplified PCR products of msp1, msp2 and glurp
Version: 1.0
Author: Mekong Molecular Surveillance Network
Preparing malaria blood smears
Procedure
Preparing thick and thin blood smears with Giemsa staining
Version: 2.0
Author: WWARN
Manual size estimation of msp1, msp2 and glurp PCR products on gel
Procedure
Manually determining the size of Plasmodium falciparum polymorphic markers to distinguish recrudesent from reinfecting infections in clinical trials
Version: 1.0
Author: Mekong Molecular Surveillance Network
DNA Extraction: Preparing Rapid Diagnostic Tests
Procedure
Storing and processing malaria Rapid Diagnostic Tests (RDTs) for DNA extraction
Version: v1.1
Author: WWARN
Estimation of Plasmodium falciparum drug susceptibility by the 3H-hypoxanthine uptake inhibition assay
Procedure
Drug susceptibility assay measuring radioactive hypoxanthine uptake in laboratory strains and fresh isolates.
Version: v1.0
Author: WWARN
glurp PCR
Procedure
PCR amplification of the polymorphic marker glurp to distinguish recrudescences from reinfections
Version: 1.0
Author: Mekong Molecular Surveillance Network