Molecular Surveyor K13 Methodology

The K13 Molecular Surveyor is an interactive map that summarises the prevalence of these molecular markers in the propeller region of the Kelch 13 gene of the malaria parasite. Find out more about the methodology behind this tool.

The data included were either shared directly with WWARN or extracted from publications and stored in a standardised secure Data Centre.

All non-synonymous mutations in the Kelch 13 gene in any codon >440 (i.e. within the propeller region) are captured along with a date of collection and geospatial information. Only samples taken before treatment are included.

To simplify the visualisation, all data within the database at the same location (even if they are from different studies) are pooled for each year. 

Each pin can be clicked to produce a box which presents more detailed information about the samples collected at that site. Within the pop-up boxes you will find links to the publications which link directly to PubMed.

The pins are coloured according to the latest agreed definitions of resistance risk (as described on the landing page);

  • A site with <5 % of isolates with any mutation in the propeller region (>440) is coloured green; that includes sites where no mutant isolates were observed,
  • ‘A site where an individual K13 propeller mutation (>440) is observed with a prevalence of ≥5% is coloured amber,
  • A site where the total prevalence of all propeller mutations is ≥10% is coloured red.

Below the map there are some other visualisations of the same data which allow the user to explore the temporal trends and compare two different sites of interest in more detail.

This is a dynamic field of research and these criteria may therefore change at any point in time

We welcome your comments, please do get in touch with us via email: molecular [at] wwarn [dot] org