Clincal Trial

Run

WWARN offers a range of free tools, resources and training opportunities to ensure that clinical data is collected to the highest standard

Once study sites are open and patient recruitment has started, clinical trial monitoring ensures adherence to the study protocol, safeguarding trial participants and making sure that data collected are of the highest achievable quality.

WWARN offers a range of free tools, resources and training opportunities to ensure that clinical data is collected to the highest standard. WWARN’s External Quality Assurance team provide proficiency testing and reference sample services that contribute to the collection of consistent, high quality trial data. 

Data management:

  • Case Record Form (CRF) template: A versatile data collection tool, the CRF template may be tailored to collect the data required by the malaria clinical research procedure for inclusion in the statistical analysis and then printed to be used in paper format
  • Database template: The WWARN database template is a flexible and easily adaptable relational database ideal for collecting longitudinal data. It can capture clinical, pharmacology and molecular data. The template is currently available on a Microsoft Access platform
  • Reciprocal monitoring: Any study site is supervised by a trained monitor from a different network clinical site. Schemes developed by the Mahidol Oxford Research Unit (MORU), Thailand (MORU) and by the East African Consortium for Clinical Research (EACCR) represent viable alternatives for monitoring health research

Improving data collection:

  • Procedures: WWARN has a growing step-by-step library of freely available procedures to support researchers both in the lab and the field. 
  • Training: We provide a selection of short, e-learning training courses in collaboration with Global Health Trials
  • Microscopy: Global Health Trials in collaboration with WWARN and with permission from the World Health Organization (WHO) – has replicated the WHO Basic Malaria Microscopy Learner’s Guide1 as a modular e-learning course.  The modular, five-part, certificated course is now freely available in the WWARN Toolkit Online Courses section
  • Proficiency testing:  WWARN has ongoing pharmacologymolecular and in vitro proficiency schemes which may be joined at any time. This scheme helps laboratories assess their ability to carry out drug analysis and resolve any potential problem areas, improving the quality of data output
  • Reference materials: WWARN is providing laboratories across the world with validated reference materials to minimise bias arising from poor-quality reference standards

1 WHO. Basic malaria microscopy – 2nd Edition. Part I Learner’s guide. Geneva, World Health Organization, 2010.