Methodology

All published antimalarial clinical trials published since 1960 were identified by the application of the key terms (listed below) through the PubMed library. All references containing any mention of antimalarial drugs were tabulated and manually checked to confirm prospective clinical trials. Studies on prevention, prophylaxis, reviews, animal studies or patients with severe malaria were excluded. When pdfs were available further details of the publications were reviewed, and basic details on the study methodology, treatment arms assessed and the study locations documented. These are provided in the WWARN publication library.

The year of the study was taken as the year in which the paper was published, although the start and end date of patient enrolment were also recorded. Where a specific site was not reported in the manuscript the capital city of the country was used as the default location. Where studies involved travellers returning from multiple endemic countries, the non-endemic country (capital city by default) of the study institution is presented.

Key terms

Literature search (conducted in 2012) used Pubmed with the following key terms (malaria OR plasmod*) AND (amodiaquine OR atovaquone OR artemisinin OR arteether OR artesunate OR artemether OR artemether OR artemotil OR azithromycin OR artekin OR chloroquine OR chlorproguanil OR cycloguanil OR clindamycin OR coartem OR dapsone OR dihydroartemisinin OR duo-cotecxin OR doxycycline OR halofantrine OR lumefantrine OR lariam OR malarone OR mefloquine OR naphthoquine OR naphthoquinone OR piperaquine OR primaquine OR proguanil OR pyrimethamine OR pyronaridine OR proguanil OR quinidine OR quinine OR riamet OR sulphadoxine OR tetracycline OR tafenoquine).