To overcome differences in study design, data must be contributed to the WWARN Data Repository on individual patients and samples. Molecular data can come from clinical efficacy trials or molecular surveys, and samples can come from many sources including finger pricks, venous blood, or in vitro isolates from infected patients, and mosquito bloodmeals.
High security measures ensure that individual data files will be accessible only to the original contributor, unless the contributor chooses to share their data with others through our secure system. For more information on the treatment of contributed data, see Contributing Data.
Variables required for each molecular submission include the following:
- Sample or patient identifier (anonymised) and date of inclusion in study
- Date of sample collection
- Genotype(s) of molecular markers of resistance including SNPs, variable length repeats and copy number polymorphisms
- Missing genotypes for any molecular markers of resistance should be designated as ‘Not Genotyped’ or ‘Genotyping Failure’
- SNP genotypes can be shared in the form of single nucleotides or amino acids or as strings
- Basic information on study site and study design
Additional variables which are valuable but NOT required include:
- Patient age (high priority, if available)
- Genotyped microsatellites in regions flanking resistance markers
- Complexity or multiplicity of infection
If molecular data are derived from patients in a clinical efficacy trial that is also being shared with WWARN, please include the required variables listed on the Clinical Data page.
Work is in progress to provide data entry templates and recommendations for study design and data collection. View the Molecular Data Management and Statistical Analysis Plan (DMSAP) for a clear and transparent description of the methodology by which WWARN handles and analyses molecular data.
