To overcome differences in study design, data must be contributed to the WWARN Data Repository on individual patients and samples. In vitro data can come from clinical efficacy trials or in vitro surveys of infected patients.
High security measures ensure that individual data files will be accessible only to the original contributor, unless the contributor chooses to share their data with others through our secure system. For more information on the treatment of contributed data, see Contributing Data.
Variables required for each in vitro submission include the following:
- Sample or patient identifier (anonymised) and date of inclusion in study
- Date of sample collection, sample parasitemia
- Basic information on study site and study protocol
- Conditions of the experimental protocol (date of test, drug concentration, etc.)
- In vitro raw data derived from the analysis of each drug tested.
Additional variables which are valuable but NOT required include:
- Patient age
- Gender
- Genotype(s) of molecular markers of resistance including SNPs, variable length repeats and copy number polymorphisms. If molecular data is included, please visit the Molecular Data page for more information about required variables.
If in vitro data are derived from patients in a clinical efficacy trial that is also being shared with WWARN, please include the required variables listed on the Clinical Data page.
View the In Vitro Data Management and Statistical Analytical Plan (DMSAP) for a clear and transparent description of the methodology by which WWARN handles and analyses in vitro data.
Work is in progress to provide data entry templates and recommendations for study design and data collection.
