The discovery of molecular markers of resistance in the Kelch 13 gene gives us the unusual opportunity to monitor the emergence and spread of resistance nearly in real time. Assessing the prevalence of these molecular markers in other regions can provide an early warning system to trigger rapid responses to develop control strategies.

The ART resistance surveyor is an interactive map that summarises the prevalence of these molecular markers in the propeller region of the Kelch 13 gene of the malaria parasite by location and year, providing a clear and standardised visualisation of the evidence to date to inform key international, regional and national monitoring strategies.

The ART resistance surveyor

  • Displays the distribution of resistance markers found on the Plasmodium falciparum malaria parasite Kelch 13 gene – one map for the distribution of molecular markers in Asia - where makers are currently most prevalent - and one map for the distribution of molecular markers in the rest of the world,
  • Displays data from over 21,538 samples from 39 published studies, covering sites in 64 countries,
  • Presents molecular analyses of K13 genotypes,
  • Flexible default settings can be altered easily by the user,
  • View countries with data on the left hand bar,
  • Discover other visualisations of the same data that allow the user to explore the temporal trends and compare two different sites of interest in more detail are available below the map.

It is not yet known whether the prevalence of certain mutations necessarily means that parasites are clinically resistant. Rather, pins are coloured on the basis of currently agreed definitions within the research and policy community as follows:

  • A site with <5 % of isolates with any mutations in the propeller region (>440) is coloured green; that includes sites where no mutant isolates were observed,
  • A site where an individual K13 propeller mutation (>440) is observed with a prevalence of ≥5% is coloured amber,
  • A site where the total prevalence of all propeller mutations is ≥10% is coloured red.

To find out more information about the tool or how to contribute data please email at molecular [at] wwarn [dot] org