Module Head — Informatics
Honorary Consultant Paediatrician, John Radcliffe Hospital, Oxford, UK
Professor of Tropical Paediatrics and MRC Clinical Research Professor, Oxford University, UK
Head of Malaria Programme, Wellcome Trust Sanger Institute
Director, MRC Centre for Genomics and Global Health, Oxford University and Wellcome Trust Sanger Institute
Supernumerary Fellow, St. John’s College, Oxford, UK
Professor Dominic Kwiatkowski is a paediatrician researching childhood diseases of the developing world. He did his research training in West Africa before going to Oxford in 1989, and since 1998 he has been an MRC Clinical Research Professor. He leads the International Child Health Group within the University Department of Paediatrics, as well as the Childhood Infection Group at Wellcome Trust Centre for Human Genetics. Dominic holds a joint appointment as a Principal Investigator at the Wellcome Trust Sanger Institute near Cambridge. The group's main research interest is malaria. They endeavour to understand fundamental biological mechanisms of disease and immunity by bringing together the complementary strengths of Sanger and Oxford, which allow them to combine new genomic technologies and statistical methodologies with large-scale clinical and epidemiological studies. One of their major tasks is to coordinate MalariaGEN, a network of researchers in 20 countries that aims to accelerate malaria vaccine development by discovering natural mechanisms of protective immunity. His team has considerable experience in using a variety of tools, including informatics, to support the development of large, multi-centre data sharing networks.
Education
1979 MBBS, Guy’s Hospital, London University, UK
1974 BA (Physiology, Psychology and Philosophy), Oxford University, UK
Professional Associations
Member, Royal College of Physicians, London, UK
Fellow, Royal College of Physicians, London
Fellow, Royal College of Paediatrics and Child Health, UK
Fellow, Academy of Medical Sciences, UK<
Representative Publications
Clark TG, Campino SG, Anastasi E, Auburn S, Teo YY, Small K, Rockett KA, Kwiatkowski DP, Holmes CC. A Baysian approach using covariance of SNP data to detect differences in linkage disequilibrium patterns between groups of individuals. Bioinformatics 2010 Jun 16.
Teo YY, Small K, Kwiatkowski DP. Challenges of genome-wide association analysis in Africa. Nature Review Genetics, 2010 Feb; 11(2):149-60 Review.
Almagro-Garcia J, Manske M, Carret C. Campino S, Auburn S, MacInnis BL, Maslen G, Pain A, Newbold CI, Kwiatkowski DP, Clark TG. SnoopCGH: software for visualising comparative genomic hybridization data. Bioinformatics 2009 Oct 15; 25(20):2732-3.
Clark TG, Fry AE, Auburn S, Campino S, Diakite M, Green A, Richardson A, Teo YY, Small K, Wilson J, Jallow M, Sisay-Joof F, Pinder M, Sabeti P, Kwiatkowski DP, Rockett KA. Allelic heterogeneity of G6PD deficiency in West Africa and severe malaria susceptibility. Eur J Hum Genet. 2009 Feb 18.
Jallow M, Teo YY, Small KS, Rockett KA, Deloukas P, Clark TG, Kivinen K, Bojang KA, Conway DJ, Pinder M, Sirugo G, Sisay-Joof F, Usen S, Auburn S, Bumpstead SJ, Campino S, Coffey A, Dunham A, Fry AE, Green A, Gwilliam R, Hunt SE, Inouye M, Jeffreys AE, Mendy A, Palotie A, Potter S, Ragoussis J, Rogers J, Rowlands K, Somaskantharajah E, Whittaker P, Widden C, Donnelly P, Howie B, Marchini J, Morris A, Sanjoaquin M, Achidi EA, Agbenyega T, Allen A, Amodu O, Corran P, Djimde A, Dolo A, Doumbo OK, Drakeley C, Dunstan S, Evans J, Farrar J, Fernando D, Hien TT, Horstmann RD, Ibrahim M, Karunaweera N, Kokwaro G, Koram KA, Lemnge M, Makani J, Marsh K, Michon P, Modiano D, Molyneux ME, Mueller I, Parker M, Peshu N, Plowe CV, Puijalon O, Reeder J, Reyburn H, Riley EM, Sakuntabhai A, Singhasivanon P, Sirima S, Tall A, Taylor TE, Thera M, Troye-Blomberg M, Williams TN, Wilson M, Kwiatkowski DP; Wellcome Trust Case Control Consortium; Malaria Genomic Epidemiology Network. Genome-wide and fine-resolution association analysis of malaria in West Africa. Nat Genet. 2009 May 24.
Mangano VD, Clark TG, Auburn S, Campino S, Diakite M, Fry AE, Green A,Richardson A, Jallow M, Sisay-Joof F, Pinder M, Griffiths MJ, Newton C, Peshu N, Parker, M, Bull, SJ, de Vries, J, Agbenyega, T, Doumbo, OK, Kwiatkowski, DP. Ethical data release in genome-wide association studies in developing countries. PLoS Med. 2009; 11, e1000143.
Manske, HM, Kwiatkowski, DP. LookSeq: a browser-based viewer for deep sequencing data. Genome Res. 2009 Nov; 19(11):2125-32.
Manske HM, Kwiatkowski DP. SNP-o-matic. Bioinformatics 2009 Sep 15; 25(18):2434-5.
Malaria Genomic Epidemiology Network. A global network for investigating the genomic epidemiology of malaria. Nature. 2008 Dec 11; 456(7223):732-7.
